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CD31 antibody may help to develop novel cardiovascular therapies

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CD31, also known as PECAM1 (platelet endothelial cell adhesion molecule 1), encodes a type I integral membrane protein and member of the immunoglobulin receptor superfamily. The CD31 antibody is widely used as an endothelial marker.

CD31 is expressed on a number of cell types, including macrophages, lymphocytes and endothelial cells, and is specifically concentrated at endothelial junctions. CD31 antibody studies have shown PECAM1 is also expressed in a number of soft tissue, vascular and endothelial tumours; the CD31 antibody database is a useful source of endothelial markers when studying angiogenesis in connection with tumour recurrence.

CD31 is expressed on the membranes of some endothelial blood-vessel cells. Recently, cardiologist Young-sup Yoon, of Emory University, published a CD31 antibody study suggesting CD31 may be significant in developing new cardiovascular therapies.

In Yoon’s study, the CD31 antibody was used in both donated human blood and mouse bone marrow cells to detect and isolate CD31(+) endothelial cells. Using an in vivo mouse model of PVD (peripheral vascular disease), it was seen that CD31(+) cells secreted hormones which supported the growth of new vasculature, enabling continued circulation through the legs. In vitro, CD31(+) cells were shown to mimic the growth of new blood vessels by developing tubular structures.

It was suggested that harvesting CD31-positive cells had several advantages over stem cells. They can be grown quickly, and do not require large volumes of patient blood or bone marrow. It is hoped the research may pave the way for novel cardiovascular disease treatments in the future.

We at Novus Biologicals have an extensive antibody database to support vascular research, to which we recently added a new CD31 antibody.

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The Article is written by novusbio.com providing antibody database and Antibodies Services. Visit http://www.novusbio.com for more information on novusbio.com Products & Services
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Reputable pharmacists supply viagra online

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Spam emails pile up in everyone’s inbox. It’s part of the daily ritual to clean out the inbox to get rid of all those unwanted messages that promise untold wealth and riches or to help get love lives back on track thanks to wonder drugs that cure impotence. And it’s this sort of thing that has given viagra a bad name. These dodgy emails and shady suppliers. When in fact there are reputable online pharmacies that can dispense the drug as well as advice and guidance. It’s just a case of people sorting the genuine pharmacists from the cowboys.

Being able to buy viagra online is a really great service. It take some of the embarrassment away that some men feel when they want to reach out for help with this problem. Getting this medication from a regular doctor or pharmacist in person isn’t the easiest thing in the world to do. By picking up viagra online, men can retain a degree of anonymity and feel much more comfortable about the whole process.

For anyone looking to buy viagra online, the best place to start is over at Euro Viagra Direct. This site is just like a virtual chemist. It’s managed and staffed by qualified pharmacists. So people can get access to the same levels of service and expertise as they would on the high street, just via the Internet instead. It’s the perfect place to obtain viagra online. They provide expert advice and guidance and offer the drug at great rates, so it’s great value too. No man needs to suffer with performance issues a moment longer. Not when this wonder drug can be obtained quickly and easily, from a reputable online pharmacist that will deliver direct to the door. It’s the perfect solution for those too shy to come forward.

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The Article is written by euroviagradirect.com providing Car service and car servicing Services. Visit http://www.euroviagradirect.com for more information on euroviagradirect.com Products & Services

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The CD95 antibody in the news

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CD95, also known as FAS or APO1, is a member of the tumor necrosis factor (TNF) superfamily. Early experiments with monoclonal antibodies identified it as a death receptor expressed on the membrane of a number of cell types, including tumor cells and lymphocytes. In a recent FAS antibody study, a single nucleotide variant of FAS was shown to have a possible protective role against malaria in children. We at Novus Biologicals have an extensive range of CD95/Fas antibodies on our antibody database.

CD95 initiates apoptosis following Fas-ligand (FasL/CD95L) binding, forming the death-inducing signaling complex (DISC ) via recruitment of caspase 8 and FADD. Cross-linking of CD95 using monoclonal antibodies has been shown to cause apoptosis of cells expressing CD95, in the same way that ligand-receptor binding does.

While the Fas ligand is primarily expressed on activated T cells and natural killer cells, the receptor protein is highly expressed in a number of other areas, including white blood cell types, and epithelial cells. In mice, it has been identified in heart, thymus, lung, liver, kidney and ovarian tissue. Alternatively spliced cDNAs, encoding a number of Fas isoforms, have been identified, and the Fas antibody is widely used in cancer research.

In normal cells, cell-specific apoptosis induced by the CD95/CD95 Ligand-binding mechanism plays a critical role in modulating the immune response. Defects in this pathway can be a cause of autoimmune disorders.

However, it appears that genetically altered variants may also have a beneficial role. In a joint study by Kumasi University, Ghana and the Bernhard Nocht Institute for Tropical Medicine in Hamburg, a variant at the human FAS locus was shown to prevent a potentially fatal immune response to malaria in children. Malaria is a major killer of children under the age of five in Africa, as unlike adults they do not have the immunity which prevents severe reactions to the parasite. CD95 antibodies revealed a genetic disposition in some children to overexpress CD95 on certain white blood cells, increasing apoptosis of these cells and muting the immune response.

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The Article is written by novusbio.com providing antibody catalogue and antibody database Services. Visit http://www.novusbio.com for more information on novusbio.com Products & Services

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The Stress Epidemic

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Stress is the biggest cause of absenteeism in the workplace. The majority of people in full time work will describe their job as stressful, and whilst technology should have reduced workloads and made the workplace easier and a more relaxing place to be, it has simply served to make industries more competitive and the workload of employees far higher and more extensive.

Stress is a global epidemic which costs business hundreds of billions of pounds every year in expenses and reduced productivity. And yet, despite the severe cost stress has to business, as well as to the individuals who suffer from the stress, very little is being done to successfully combat the issue.

Very simple changes within the workplace could easily help to ensure that a huge amount of stress is reduced for employees. Looking at occupational health recruitment will be a very cost-effective way of ensuring that not only are employees physically safe, but also mentally safe too. Occupational health recruitment can also be looked into on a short term basis, having regular reviews to ensure that your workplace processes are geared effectively towards keeping your staff happy and healthy.

Whilst many think that productivity will come through pressure and through increasing workloads, the opposite is very much true, and whether you outsource certain areas during busy periods or simply create a more inclusive and calm environment, you will usually find that productivity increases rather than decreases and that the chances of absenteeism and therefore cost related to stress fall dramatically.

For those who want to help combat the rising epidemic of stress, training for or finding occupational health jobs could be the perfect way to ensure your skills really make a difference, not just to companies but to the individuals who really matter. There are many different jobs in occupational health and the more people there are to help combat these problems, the happier and healthier we will all be.

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The Article is written by ohrecruitment.co.uk providing occupational health jobs and occupational health recruitment Services. Visit http://www.ohrecruitment.co.uk for more information on ohrecruitment.co.uk Products & Services
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True Tantric Massage

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The ancients knew the value of taking your time, and that’s the very essence of tantric massage. Based in ancient Taoist philosophy, the tantra teaches us that nothing – especially sensual pleasures should be rushed. If you are looking for tantric massage in London then you will be looking for a service that understands these ancient and respected beliefs, you will be requiring a lady who understands that a massage in London can be a spiritual as well as a physical experience. You’ll require that the masseur understand that sensual pleasure comes from preparation and delay and the communion between two souls on a spiritual level.

So many services offering massage in London claim to offer their client’s tantric massage without understanding the fundamentals of the tantric teachings which dwell on slow, subtle and sensual spiritual stimulation. Rest assured that our masseurs are fully aware of what offering tantric massage in London really means and do not offer the exotic promise of something they do not understand and cannot deliver.

For us, it is our customers overall satisfaction that concerns us as well as the massage itself. Indeed this is truly in the spirit of the tantra, which advocates the meeting of all physical, mental and spiritual needs in a mature, pen-minded and relaxed environment. For us your entire visit will be a sophisticated, calming and sensual experience from the moment you step through our door. But the experience does not end once you leave us, the feelings of good-will and tranquil ease inspired by a tantric massage will be with you for lasting days after you have left us. For believers in the tantra a tantric massage does more than ease your aches and relieve your mental anxieties, but reaches into your heart and awakens long dormant feelings of joy and peace that exist in the core of all our hearts.

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The Article is written by firstclassmassagelondon.co.uk providing london massage and erotic massage london Services. Visit http://www.firstclassmassagelondon.co.uk for more information on firstclassmassagelondon.co.uk Products & Services
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